Image quality and radiopharmaceutical parameters of Indium-111 granulocytes in scintigraphy of inflammatory bowel disease
Identifieur interne : 000486 ( Main/Exploration ); précédent : 000485; suivant : 000487Image quality and radiopharmaceutical parameters of Indium-111 granulocytes in scintigraphy of inflammatory bowel disease
Auteurs : RBID : ISTEX:259_1989_Article_BF00253794.pdfEnglish descriptors
Abstract
This study was undertaken to investigate the influence of various parameters of injected autologous 111In labelled granulocytes on scintigraphic image quality. Forty-two scintigrams of 37 patients with inflammatory bowel disease were evaluated. The images were divided into three groups according to quality: good, intermediate and poor. The relationships between image quality and such radiopharmaceutical parameters as injected dose of 111In, number of injected cells and specific activity were investigated. It appeared that in order to obtain interpretable images, a specific activity of at least 85 kBq 111In/million cells was necessary. The activity of the injected dose must exceed 7 MBq if poor quality images and very long acquisition times are to be avoided.
DOI: 10.1007/BF00253794
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Box 9600, 2300 RC, Leiden, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden</wicri:regionArea><wicri:noRegion>Leiden</wicri:noRegion></affiliation></author><author><name>A. S. Pena</name></author><author><name>R. T. O. T. A. Tham</name><affiliation wicri:level="1"><mods:affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden</wicri:regionArea><wicri:noRegion>Leiden</wicri:noRegion></affiliation></author><author><name>I. T. Weterman</name></author><author><name>C. B. H. W. Lamers</name></author><author><name>E. K. J. Pauwels</name><affiliation wicri:level="1"><mods:affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden</wicri:regionArea><wicri:noRegion>Leiden</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:259_1989_Article_BF00253794.pdf</idno><date when="1989">1989</date><idno type="doi">10.1007/BF00253794</idno><idno type="wicri:Area/Main/Corpus">000732</idno><idno type="wicri:Area/Main/Curation">000732</idno><idno type="wicri:Area/Main/Exploration">000486</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Image quality</term><term>Inflammatory bowel disease</term><term>Leukoscintigraphy</term><term>111In-granulocytes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">This study was undertaken to investigate the influence of various parameters of injected autologous 111In labelled granulocytes on scintigraphic image quality. Forty-two scintigrams of 37 patients with inflammatory bowel disease were evaluated. The images were divided into three groups according to quality: good, intermediate and poor. The relationships between image quality and such radiopharmaceutical parameters as injected dose of 111In, number of injected cells and specific activity were investigated. It appeared that in order to obtain interpretable images, a specific activity of at least 85 kBq 111In/million cells was necessary. The activity of the injected dose must exceed 7 MBq if poor quality images and very long acquisition times are to be avoided.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="7e6e8715a5038f00083c1950632f4322906d1f4d"><titleInfo lang="eng"><title>Image quality and radiopharmaceutical parameters of Indium-111 granulocytes in scintigraphy of inflammatory bowel disease</title></titleInfo><name type="personal"><namePart type="given">J. W.</namePart><namePart type="family">Arndt</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</affiliation></name><name type="personal"><namePart type="given">G. E.</namePart><namePart type="family">Crama-Bohbouth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. W.</namePart><namePart type="family">Verspaget</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Blok</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</affiliation></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Pena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. T. O. T. A.</namePart><namePart type="family">Tham</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</affiliation></name><name type="personal"><namePart type="given">I. T.</namePart><namePart type="family">Weterman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. B. H. W.</namePart><namePart type="family">Lamers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. K. J.</namePart><namePart type="family">Pauwels</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Department of Diagnostic Radiology, Division of Nuclear Medicine, University Hospital, Building 1, C4-Q, P.O. Box 9600, 2300 RC, Leiden, The Netherlands</affiliation></name><typeOfResource>text</typeOfResource><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1988-05-20</dateCreated><dateCaptured encoding="w3cdtf">1988-11-16</dateCaptured><dateValid encoding="w3cdtf">2004-08-06</dateValid><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">This study was undertaken to investigate the influence of various parameters of injected autologous 111In labelled granulocytes on scintigraphic image quality. Forty-two scintigrams of 37 patients with inflammatory bowel disease were evaluated. The images were divided into three groups according to quality: good, intermediate and poor. The relationships between image quality and such radiopharmaceutical parameters as injected dose of 111In, number of injected cells and specific activity were investigated. It appeared that in order to obtain interpretable images, a specific activity of at least 85 kBq 111In/million cells was necessary. The activity of the injected dose must exceed 7 MBq if poor quality images and very long acquisition times are to be avoided.</abstract><subject lang="eng"><genre>Key words</genre><topic>111In-granulocytes</topic><topic>Image quality</topic><topic>Inflammatory bowel disease</topic><topic>Leukoscintigraphy</topic></subject><relatedItem type="series"><titleInfo type="abbreviated"><title>Eur J Nucl Med</title></titleInfo><titleInfo><title>European Journal of Nuclear Medicine</title><partNumber>Year: 1989</partNumber><partNumber>Volume: 15</partNumber><partNumber>Number: 4</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1989-04-01</dateIssued><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><subject usage="primary"><topic>Medicine & Public Health</topic><topic>Imaging / Radiology</topic><topic>Nuclear Medicine</topic></subject><identifier type="issn">0340-6997</identifier><identifier type="issn">Electronic: 1619-7089</identifier><identifier type="matrixNumber">259</identifier><identifier type="local">IssueArticleCount: 17</identifier><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF00253794</identifier><identifier type="matrixNumber">Art8</identifier><identifier type="local">BF00253794</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>197</start><end>200</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1989</recordOrigin><recordIdentifier>259_1989_Article_BF00253794.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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